Influence of the Type of Anionic Polysaccharide in the Preparation of Microcapsules. Effect of pH Change

• Rafael Bolívar Universidad de Carabobo, Venezuela
• Ingrid Velásquez Universidad de Carabobo, Venezuela https://orcid.org/0000-0002-5522-0161
• Ruth Monroy Universidad de Carabobo, Venezuela https://orcid.org/0000-0003-2523-5511

DOI: https://doi.org/10.5281/zenodo.20158850

Keywords: Microencapsulation, Anionic polysaccharide, Controlled release, Hydrophobic compounds

Abstract

Microencapsulation is a technology for coating solids, liquids and gases with materials of different nature, to create micrometric-sized capsules that can release their contents in a controlled manner under the influence of specific conditions such as pH and temperature. The choice of method depends on the size to be achieved, while the properties of the coating material depend on the polymer used, whose function is to protect the encapsulated material, as well as respond to a stimulus to subsequently release said compound. The aim of this research was to establish the effect of the type of anionic polysaccharide in a polysaccharide-protein complex on the production of microcapsules for hydrophobic compounds, when these are released under the stimulus of the pH of the medium. The microcapsules were formed by complex coacervation, forming the BSA-CMC and BSA-Pectin systems, with spherical microcapsules smaller than 60 µm. The process yield was between 80 and 84%, depending on the polysaccharide. When stimulated by changes in the pH of the medium, the encapsulated compound was released, resulting in a more sensitive BSA-Pectin complex compared to BSA-CMC. This behavior allows establishing the applicability of these complexes when hydrophobic compounds are to be released under pH stimulation.

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