Efectos de la suplementación de zinc en aleaciones de magnesio sobre el hemograma y la fragilidad osmótica de los eritrocitos

• Semih Yaşar Van Yuzuncu Yil University,Department of Medical Laboratory Technics, Ozalp Vocational High School, Van, Türkiye https://orcid.org/0000-0003-2754-6030
• Arzu Comba Hitit University, Department of Laboratory Technology, Technical Sciences Vocational School. Corum, Türkiye. https://orcid.org/0000-0001-9462-8998
• Leyla Mis Van Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Physiology, Van, Türkiye. https://orcid.org/0009-0003-9795-8599
• Bünyamin Çiçek Hitit University, Department of Laboratory Technology, Technical Sciences Vocational School. Corum, Türkiye. https://orcid.org/0000-0002-6603-7178
• Bahat Comba Hitit University, Department of Laboratory Technology, Technical Sciences Vocational School. Corum, Türkiye. https://orcid.org/0000-0002-3419-4144
• Tunahan Sancak Sivas Cumhuriyet University, Faculty of Veterinary Medicine, Department of Surgery. Sivas, Türkiye. https://orcid.org/0000-0002-7813-1575

DOI: https://doi.org/10.52973/rcfcv-e362929

Palabras clave: Biocompatibilidad, fragilidad, hemograma, aleación de magnesio, aleación de zinc

Resumen

El magnesio y el zinc son oligoelementos que desempeñan funciones importantes en el metabolismo, la función inmunitaria y la formación de células sanguíneas. Se estudiaron los efectos de la suplementación dietética con magnesio y zinc en los parámetros de eritrocitos, leucocitos, plaquetas y fragilidad osmótica de los eritrocitos. Se implantaron varias aleaciones de magnesio - zinc en ratas en el músculo próximo al fémur. Los animales se dividieron en siete grupos y en la cuarta y séptima semanas se recogieron muestras de sangre para el análisis del hemograma y la prueba de fragilidad osmótica. Los grupos fueron: Control, magnesio (cuarta y séptima semana), magnesio + zinc1 (cuarta y séptima semana) y magnesio + zinc3 (cuarta y séptima semana). Los valores de volumen corpuscular medio y amplitud  de distribución  eritrocitaria fueron significativamente   más altos en el grupo magnesio + zinc3 (semana 4), mientras que el valor de volumen corpuscular medio fue más bajo en el grupo magnesio (semana 7). Se observó una disminución en el recuento y el porcentaje de linfocitos solo en el grupo magnesio + zinc1 (semana 4), mientras que el aumento se encontró en el grupo magnesio (semana 7). El recuento y el porcentaje  de  neutrófilos  aumentaron  significativamente en magnesio + zinc1 (semana 4), mientras que, disminuyeron en ambos grupos de magnesio + zinc en la semana 7. Los niveles de hemólisis en una concentración de cloruro de sodio al 0,4 % y 0,5 % no fueron inferiores al 94 y 86 %, respectivamente, para el grupo magnesio + zinc3 (semana 7). Parece que la mezcla magnesio + zinc puede tener un efecto sobre la eritropoyesis y podría producir macrocitosis, así como cambios de anisocitosis, que podrían normalizarse con el tiempo por adaptación fisiológica. Los incrementos estables logrados en el grupo magnesio también indican un papel más constante del magnesio en la homeostasis de los elementos sanguíneos.

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