Comparative efficacy of octreotide and somatostatin in acute pancreatitis: a controlled trial of inflammatory markers and hospital length of stay.

Eficacia comparada de octreótido y somatostatina en pancreatitis aguda: ensayo controlado sobre marcadores inflamatorios y duración de la estancia hospitalaria.

• Qunchao Zhu Department of Emergency Medicine, The First People’s Hospital of Jiashan, Jiashan Hospital Affiliated of Jiaxing University, Jiashan, Zhejiang Province, China. https://orcid.org/0009-0004-6987-6091
• Tian Jiang Department of Thoracic Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi Province, China. https://orcid.org/0009-0002-5083-5500
• Yan Li Department of Endocrinology, Jiujiang Hukou County People’s Hospital, Hukou, Jiangxi Province, China. https://orcid.org/0009-0002-4819-7941
• Sicong Jiang Department of Emergency Medicine, The First People’s Hospital of Jiashan, Jiashan Hospital Affiliated of Jiaxing University, Jiashan, Zhejiang Province, China. https://orcid.org/0000-0001-8974-6770
• Aifang Li Department of Hematology, Jiamusi University Affiliated First Hospital, Jiamusi, Heilongjiang Province, China. https://orcid.org/0009-0008-7880-6078
• Chendong Ma Department of Emergency Medicine, The First People’s Hospital of Jiashan, Jiashan Hospital Affiliated of Jiaxing University, Jiashan, Zhejiang Province, China. https://orcid.org/0009-0003-3787-5468

DOI: https://doi.org/10.54817/IC.v67n2a03

Keywords: Acute Pancreatitis, Octreotide, Somatostatin, Inflammation, Hospitalization

Abstract

Acute pancreatitis is an acute pancreatic injury with multiple etiologies. Octreotide and somatostatin are commonly used treatments, but their clinical efficacy remains controversial. This study compares their effects on inflammatory markers and hospital length of stay. One hundred and twenty patients with acute pancreatitis admitted to The First People’s Hospital of Jiashan between January 2022 and December 2024 were retrospectively included and divided into two groups based on treatment modality, namely the control group (somatostatin treatment) and the experimental  group  (octreotide  treatment), with 60 cases in each group. Serum amylase (AMY), serum lipase (LPS), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), white blood cell count (WBC), serum albumin (ALB) content, procalcitonin (PCT), hos- pital stay duration, and the incidence of adverse reactions were assessed in both groups. Baseline data for the two groups were comparable, with no statistically significant differences (p>0.05). After seven days of medication, compared with the control group, patients in the experimental group had lower AMY, LPS, CRP, IL-6, TNF-α, WBC, and PCT (p<0.05), a shorter hospital stay (p=0.011), and a lower incidence of adverse reactions (p=0.007). ALB levels in the experimental group were significantly higher than those in the control group (p=0.039). Compared with somatostatin, octreotide shows superior therapeutic effects in acute pancreatitis, alleviating inflammation more effectively, promoting recovery, improving clinical outcomes, and shortening hospital stay. These findings provide a scientific basis for optimizing clinical medication.

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