Expressions of Lipocalin-2 in nasal tissues and secretions of patients with chronic rhinosinusitis with nasal polyps and correlations with inflammatory factors.:

Yang  Li; Youxiong  Yang; Jun  Xu; Yun  Zhu

doi:10.54817/IC.v67n2a01

Yang Li Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Hospital of Integrated Traditional Chinese and Western Medicine, Ningbo 315100, Zhejiang Province, China. https://orcid.org/0009-0000-9633-8038
Youxiong Yang Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Hospital of Integrated Traditional Chinese and Western Medicine, Ningbo, Zhejiang Province, China. https://orcid.org/0009-0007-3967-2559
Jun Xu Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Hospital of Integrated Traditional Chinese and Western Medicine, Ningbo, Zhejiang Province, China. https://orcid.org/0009-0003-8658-8537
Yun Zhu Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Hospital of Integrated Traditional Chinese and Western Medicine, Ningbo, Zhejiang Province, China. https://orcid.org/0009-0008-7955-5530

DOI: https://doi.org/10.54817/IC.v67n2a01

Keywords: Inflammation Mediators, Lipocalin-2, Nasal polyps, Rhinosinusitis

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disease of the upper airway. Lipocalin-2, an inflammation-related glycoprotein involved in innate immune regulation, has been linked to several chronic inflammatory disorders, but its role in CRSwNP remains unclear. This study aimed to examine the expression of Lipocalin-2 in nasal tissues and secretions of CRSwNP patients and its relationship with inflammatory factors. Seventy patients diagnosed with CRSwNP between January 2023 and January 2025 were enrolled in the case group, while 60 patients with simple nasal septal deviation served as controls. NP tissues and nasal secretions were collected from CRSwNP patients, whereas inferior turbinate mucosal tissues and nasal secretions were obtained from controls. Levels of Lipocalin-2, interleukin-5 (IL -5), IL -6, and tumor necrosis factor-alpha (TNF-α) were measured and analyzed. Compared with controls, CRSwNP patients showed significantly higher levels of Lipocalin-2 and inflammatory cytokines in nasal secretions (p<0.05). Stratification based on Visual Analog Scale (VAS) scores and computed tomog- raphy Lund-Mackay (CT L -M) scores indicated that these markers were notably higher in the moderate-to-severe group than in the mild disease group (p< 0.05). Lipocalin-2 was positively correlated with IL -5, IL -6, TNF-α, as well as VAS, Lund-Kennedy endoscopy, and CT L -M scores (all p<0.05). In summary, Lipocalin-2 is highly expressed in nasal polyp tissues and secretions of CRSwNP patients and closely associated with inflammatory cytokine levels and clinical severity, implying its potential as a biomarker for disease activity in CRSwNP.

Downloads

Download data is not yet available.

References

Chan Y, Thamboo AV, Han JK, Desrosiers M. Remission: does it already exist in chronic rhinosinusitis with nasal polyposis? J Otolaryngol Head Neck Surg. 2023; 52(1): 50. https://doi.org/10.1186/s40463-023-00657-2

Julka BS, Patil SB, Chandrakiran C. Incidence and Prevalence of Fungal Sinusitis in Cases of Chronic Rhinosinusitis. Indian J Otolaryngol Head Neck Surg. 2023; 75(Suppl 1): 1041-1046. https://doi.org/10.1007/s12070-023-03572-0

Viksne RJ, Sumeraga G, Pilmane M. Antimicrobial and Defense Proteins in Chronic Rhinosinusitis with Nasal Polyps. Medicina. 2023; 59(7): 1259. https://doi.org/10.3390/medicina59071259

Liu X, Charn TC, Wang DY. Mepolizumab in chronic rhinosinusitis with nasal polyposis. Immunotherapy. 2023; 15(14): 1105-1116. https://doi.org/10.2217/imt-2023-0026

Norwood TG, Grayson JW, Woodworth BA. Advances in Sinus Surgery for Nasal Polyps. Am J Rhinol Allergy. 2023; 37(2): 162-167. https://doi.org/10.1177/19458924221147783

Schröder SK, Gasterich N, Weiskirchen S, Weiskirchen R. Lipocalin 2 receptors: facts, fictions, and myths. Front Immunol. 2023; 14: 1229885. https://doi.org/10.3389/fimmu.2023.1229885

Pelaia G, Aiello V, Tinello C, Chiarella E, Piazzetta GL, Lobello N, et al. Eosinophil-targeted treatment strategies for long-term outcomes in severe eosinophilic asthma. Expert Rev Respir Med. 2025; 19(8):827-842. https://doi.org/10.1080/17476348.2025,2506551

Tysome JR. Clinical Otolaryngology: Changing of the guard. Clin Otolaryngol. 2020; 45(1): 1. https://doi.org/10.1111/coa.13482

Johnson EW. Visual analog scale (VAS). Am J Phys Med Rehabil. 2001; 80(10): 717. https://doi.org/10.1097/00002060-200110000-00001

Zhang Y, Jiang H, Long Y, Li J. The Evaluation Value of the Modified Lund-Kennedy Nasal Endoscopy Score on the Efficacy of Sublingual Immunotherapy for Allergic Rhinitis. Am J Rhinol Allergy. 2024; 38(6): 366-372. https://doi.org/10.1177/19458924241269786

Do BA, Lands LC, Mascarella MA, Fanous A, Saint-Martin C, Manoukian JJ, et al. Lund-Mackay and modified Lund-Mackay score for sinus surgery in children with cystic fibrosis. Int J Pediatr Otorhinolaryngol. 2015; 79(8): 1341-1345. https://doi.org/10.1016/j.ijporl.2015.06.007

Bandi S, Stephen E, Bansal K, Mahdavinia M. Understanding the CRSWNP Patient as Whole. Am J Rhinol Allergy. 2023: 37(2): 140-146. https://doi.org/10.1177/19458924231152671

Gong MJ, Wang YS, Lou M, Ma RP, Hu ZZ, Zheng GX, et al. A new marker for predicting postoperative recurrence of CRSWNP. Acta Otolaryngol. 2023; 143(2): 170-175. https://doi.org/10.1080/00016489.2023.2168054

Shah SA, Kobayashi M. Pathogenesis of chronic rhinosinusitis with nasal polyp and a prominent T2 endotype. Heliyon. 2023; 9(9): e19249. https://doi.org/10.1016/j.heliyon.2023.e19249

Galaris A, Fanidis D, Tsitoura E, Kane-Ilopoulou P, Barbayianni I, Ntatsoulis K, et al. Increased lipocalin-2 expression in pulmonary inflammation and fibrosis. Front Med. 2023; 10: 1195501, https://doi.org/10.3389/fmed.2023.1195501

Marques E, Alves Teixeira M, Nguyen C, Terzi F, Gallazzini M. Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation. Cell Rep. 2023; 42(9): 113032. https://doi.org/10.1016/j.celrep.2023.113032

Živalj M, Van Ginderachter JA, Stijlemans B. Lipocalin-2: A Nurturer of Tumor Progression and a Novel Candidate for Targeted Cancer Therapy. Cancers. 2023; 15(21): 5159. https://doi.org/10.3390/cancers15215159

Sonmez Kaplan S, Sazak Ovecoğlu H, Genc D, Akkoc T. TNF-a, IL-1B and IL-6 affect the differentiation ability of dental pulp stem cells. BMC Oral Health. 2023; 23(1): 555. https://doi.org/10.1186/$12903-023-03288-1

Simpson CA, Santoro AM, Carpenter TO, Deng Y, Parziale S, Insogna KL. Circulating Levels of Leptin and Lipocalin-2 in Patients With X-Linked Hypophosphatemia. J Endoer Soc. 2023; 7(11): bvad116. https://doi.org/10.1210/jendso/bvad116

Stisen ZR, Nielsen SM, Ditlev SB, Skougaard M, Egeberg A, Mogensen M, et al. Treatment-related changes in serum neutrophil gelatinase-associated lipocalin (NGAL) in psoriatic arthritis: results from the PIPA cohort study. Scand J Rheumatol. 2024; 53(1): 21-28. https://doi.org/10.1080/03009742.2023.2216046

Vogan K. Immunotherapy for ankylosing spondylitis. Nat Genet. 2023; 55(12): 2020. https://doi.org/10.1038/s41588-023-01612-7

Cvetko Krajinović L, Bodulić K, Laškaj R, Žibrat B, Svoboda Karić P, Kurolt IC, et al. Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP. Life. 2023; 13(11): 2189. https://doi.org/10.3390/life13112189.

Expressions of Lipocalin-2 in nasal tissues and secretions of patients with chronic rhinosinusitis with nasal polyps and correlations with inflammatory factors.

Expresión de Lipocalina-2 en los tejidos nasales y secreciones de pacientes con rinosinusitis crónica con pólipos nasales y su correlación con factores inflamatorios.

Abstract

Downloads

References