Clinical case: Restrictive cardiac patient due to pericardial lymphoma

• Sebastián Brocell-Villao Universidad Católica de Cuenca. Cuenca, Azuay, Ecuador
• Estefanía Zúñiga-Cobos Centro Integral Veterinario de la Ciudad de Guayaquil. Guayaquil, Guayas, Ecuador https://orcid.org/0000-0002-2381-1805

DOI: https://doi.org/10.52973/rcfcv-e32169

Keywords: Lymphoma, mass, echocardiography, heart, cardiology

Abstract

Canine patient (Canis lupus familiaris) sterilized female, 8-year-old, mixed breed, who was treated at the Comprehensive Veterinary Center of the City of Guayaquil, Ecuador, on November 1, 2021, reports a clinical picture characterized by asthenia, anorexia, temperature evaluated at 39.5°C and dyspnea at medium exertion. Physical examination revealed poor general condition, pale and dry skin, hypophonetic heart sounds, distended abdomen with a positive ballooning sign. At clinic, an A-Fast (Focused assessment with sonography in trauma) was performed in which free fluid was observed in the 4 quadrants, when performing a T-Fast ultrasound examination (Thoraic Focussed assessment with sonography in trauma), pericardial effusion was observed. In a subsequent consultation, a pericardiocentesis was performed by the cardiologist who extracted 40 milliliters (mL) whose content was analyzed by cytology, which showed monomorphic lymphoblastic cells with aberrant mitoses that suggested a diagnosis of lymphoma. Echocardiography revealed a mass at the base of the heart (within the visceral pericardium and heart), which was removed by surgery and a sample was sent to the pathology laboratory, whose diagnostic report was compatible with grade II diffuse intermediate cell lymphoma.

References

AUPPERLE, H.; MÄRZ, I.; ELLENBERGER, C.; BUSCHATZ, S.; REISCHAUER, A.; SCHOON, H. Primary and secondary heart tumours in dogs and cats. J. Comp. Pathol. 136(1): 18–26. 2007. https://doi.org/fqd89j.

ABUSHOUK, A.I; ISMAIL, A.; AFIFI, A. Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity. Biomed. Pharmacother. 90: 935–946. 2017. https://doi.org/gbhddg.

BODDY, K.N.; SLEEPER, M.M.; SAMMARCO, C.D.; WEISSE, C.; GHODS, S.; LITT, H.I. Cardiac magnetic resonance in the differentiation of neoplastic and nonneoplastic pericardial effusion. J. Vet. Intern. Med. 25(5): 1003–1009. 2011. https://doi.org/cgfmtk.

CARRIÓN-LOJÁN, D.C. Resección de hemangiosarcoma de base cardíaca con autosutura GIA en un pastor alemán de 3 años reporte de caso. Universidad San Francisco de Quito, Colegio de Ciencias de la Salud; Quito, Ecuador. Tesis de Grado. Pp 13–18. 2019.

HANSEN, K.; THÉON, A.; WILLCOX, J.; STERN, J. Long-term outcomes with conventional fractionated and stereotactic radiotherapy for suspected heart-base tumours in dogs. Vet. Comp. Oncol. 19(1): 191–200. 2021. https://doi.org/h93d.

LARA, A. Actualización en el tratamiento del linfoma canino y felino. Linfoma canino. Actualización en el tratamiento del Linfoma canino y felino. Congreso de Especialidades Veterinarias. Granada, 5/6-13, España. Pp 3–4. 2013.

LEGENDRE, A.M. Treatment of Dogs with Lymphoma: A Work in Progress. J. Vet. Intern. Med. 21(6): 1166–1167. 2007. https://doi.org/chjbwn.

LINCE, R.; DE MESA, C.G.; ARTEAGA, A.; MONTOYA, J.; VÁSQUEZ, L.M. Rabdomioma cardiaco como manifestación de esclerosis tuberosa. Presentación de dos casos y revisión de la literatura. Rev. Colomb. Cardiol. 16(5): 224–228. 2009.

MACDONALD, K.A.; CAGNEY, O.; MAGNE, M.L. Echocardiographic and clinicopathologic characterization of pericardial effusion in dogs: 107 cases (1985–2006). J. Ame. Vet. Med. Assoc. 235(12): 1456–1461. 2009. https://doi.org/bz9ndd.

MACGREGOR, J.M.; FARIA, M.L.E.; MOORE, A.S.; TOBIAS, A.H.; BROWN, D.J.; DE MORAIS, H.S.A. Cardiac lymphoma and pericardial effusion in dogs: 12 cases (1994–2004). J. Ame. Vet. Med. Assoc. 227(9): 1449–1453. 2005. https://doi.org/brb4tr.

SALINAS, C.E.; DÁVILA, F.R.; CHÁVEZ, R.E. Hemangiosarcoma Cardiaco Primario en Aurícula Derecha en un Canino Rottweiler de Ocho Años de Edad. Rev. Invest. Vet. Perú. 27(4): 1039–1046. 2017. https://doi.org/h93f.

SHAW, S.P.; RUSH, J.E. Canine pericardial effusion: Diagnosis, treatment, and prognosis. Compend. Contin. Educ. Vet. 29(7): 405–411. 2007.

SIMS, C.S.; TOBIAS, A.H.; HAYDEN, D.W.; FINE, D.M.; BORJESSON, D.L. Pericardial Effusion Due to Primary Cardiac Lymphosarcoma in a Dog. J. Vet. Intern. Med. 17(6): 923–927. 2003. https://doi.org/cxcxzt.

TREGGIARI, E.; PEDRO, B.; DUKES–MCEWAN, J.; GELZER, A.R.; BLACKWOOD, L.A descriptive review of cardiac tumours in dogs and cats. Vet. Comp. Oncol. 15(2): 273–288. 2017. https://doi.org/h93g.

TONG, L.; BENNETT, S.; THOMPSON, D.; ADSETT, S.; SHIEL, R. Right–sided congestive heart failure in a dog because of a primary intracavitary myocardial lymphoma. Austr. Vet. J. 93(3): 67–71. 2015. https://doi.org/f636hf.

WARE, W.A.; HOPPER, D.L. Cardiac tumors in dogs: 1982–1995. J. Vet. Intern. Med. / Ame. College Vet. Intern. Med. 13(2): 95–103. 1999. https://doi.org/b2m5zk.