Rosa damascena extract is as effectıve as Centella asiatica in wound healing

• Mehmet Nuri Yildiz University of Health Sciences Gazi Yaşargil, Department of Surgical Medical Sciences,Training and Research Hospital, Diyarbakır, Turkey.
• Abidin Tüzün University of Health Sciences Gazi Yaşargil, Department of Surgical Medical Sciences,Training and Research Hospital, Diyarbakır, Turkey. https://orcid.org/0000-0002-4953-6602
• Hüseyin Bilge University of Health Sciences Gazi Yaşargil, Department of Surgical Medical Sciences,Training and Research Hospital, Diyarbakır, Turkey. https://orcid.org/0000-0001-7203-2288
• Eda Yildizhan Dicle University, Faculty of Medicine, Department of Histology and Embryology, Diyarbakır, Turkey. https://orcid.org/0000-0002-5648-6498
• Alpay Cetin University of Health Sciences, Department of Pathology,Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey. https://orcid.org/0000-0002-1499-6799

DOI: https://doi.org/10.52973/rcfcv-e361759

Keywords: Wound healing, Rosa damascena, Centella asiatica, VEGF

Abstract

Since prolonged wound healing processes not only compromise patient comfort but also increase patient care costs, extracts obtained from various plants are preferred in clinical and experimental studies to accelerate wound healing and contribute to curation. The aim was to compare the efficacy of Centella asiatica, whose effectiveness on wound healing has been proven in previous studies, with that of Rosa damascena, for which research is still ongoing. Twenty-one Wistar albino rats aged 8-10 weeks were used in the study. The rats’ back region was shaved with a shaving machine, cleaned with physiological serum, and a 2x2 cm incision was made to create a full-thickness excisional wound in the interscapular area. Group I: Control group, Group II: Rosa damascena group, Rosa damascena extract was applied once a day and dressed with gauze. Group III: Centella asiatica group received a similar application. The wound surface dimensions were measured on days 0, 7, 14, and 21 by drawing on acetate paper to calculate the surface area. On days 7, 14, and 21, punch biopsies were taken from different areas for histopathological examination. On day 14, no significant difference was observed between Rosa damascena and Centella asiatica in terms of wound surface area (P = 0.415). Again, no statistically significant difference was observed between the groups in terms of fibroblast activity on days 7 and 21, and neovascularization was also found to be insignificant on days 14 and 21. Collagen regularity and density increased in both the Rosa damascena group and the  Centella asiatica group.  VEGF retention  did not show a significant difference between the two groups on day 21 (P = 0.762). It was concluded that Rosa damascena extract may contribute to wound healing more effectively than Centella asiatica ointment.

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