Lipids, Malnutrition and Dengue Infection: Association or repercussion?

  • Nereida Josefina Valero Cedeño Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. http://orcid.org/0000-0003-3496-8848
  • Teresa Isabel Veliz-Castro Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. http://orcid.org/0000-0002-0324-775X
  • Pincay Parrales Edison Gastón Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. http://orcid.org/0000-0001-6161-3327
  • Karina Maricela Merchán-Villafuerte Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí. http://orcid.org/0000-0003-1500-7304
  • Jenifer Gotera Universidad del Zulia. Facultad de Medicina. Escuela de Bioanálisis. Departamento Salud Pública y Social. Maracaibo-Zulia. http://orcid.org/0000-0002-2386-0842
DOI: https://doi.org/10.5281/zenodo.3766279
Keywords: dengue, lipids

Abstract

El dengue ha sido reconocido como una de las arbovirosis más importantes en la actualidad. Aunque esta enfermedad cursa como una infección autolimitada en la mayoría de los casos, algunos pacientes pueden desarrollar desde la forma leve definida como dengue sin signos de alarma (DSSA) a formas más severas, el dengue con signos de alarma (DCSA) y el dengue grave (DG) potencialmente mortal. Se han propuesto varias hipótesis derivadas de investigaciones in vivo e in vitro, donde destacan como factores de riesgo para enfermedad severa la infección secuencial de dengue, la raza, edad, género, genética poblacional y el estado nutricional del huésped; sin dejar de mencionar las características propias inherentes a la cepa viral infectante, mecanismos de evasión del sistema inmunológico, las reacciones de citotoxicidad mediada por anticuerpos, la activación de proteínas del sistema de complemento, factores activadores y de consumo plaquetario, así como también la
cascada de citocinas. La inmunoamplificación mediada por anticuerpos (ADE, por sus siglas en inglés) ha sido propuesta como el principal factor predisponente del DG (1,2); sin embargo, no todos los casos pueden explicarse con esta teoría, sugiriendo la participación de otros mecanismos. En la patogénesis de esta infección existen aún muchas interrogantes por responder y la identificación oportuna de pacientes con alto riesgo a desarrollar DG sigue siendo un reto.

Author Biography

Nereida Josefina Valero Cedeño, Universidad Estatal del Sur de Manabí. Facultad de Ciencias de la Salud. Carrera de Laboratorio Clínico. Jipijapa-Manabí.

Degree in Bioanalysis. Magister Scientiarum in Biology, Mention Basic Immunology. Doctor in Immunology. Postdoctorate in Immunology and Infectious Diseases. Teacher-Researcher hired. Clinical Laboratory Career. Faculty of Health Sciences. Southern State University of Manabi. Manabí-Ecuador, among the different positions held, are former Director of the Institute of Clinical Research “Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Former head of the Virology Section. Institute of Clinical Research. "Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Former director of the Research Division of the Faculty of Medicine, Universidad del Zulia. Maracaibo Venezuela. Ex-coordinator of the Research Master in Biomedicine. Institute of Clinical Research. "Dr. Américo Negrette. ” Faculty of Medicine, University of Zulia. Maracaibo Venezuela. Ex-coordinator of the Master in Infectious Diseases of the University of Alcalá, Spain. Professional experience in the areas of immunology and virology. His research focuses on the diagnosis and epidemiology of emerging and reemerging viral infections such as Venezuelan equine encephalitis, dengue fever, yellow fever and respiratory syncytial virus among others. He has presented numerous communications to congresses and lectured at national and international scientific events. He has published more than 110 scientific papers in refereed journals, as well as reviews, chapters in books and monographs, both nationally and internationally. Member of the Editing Commission and expert evaluator in the area of immunology and virology of the Clinical Research Journals, Kasmera, REDIELUZ, Medical Journal of the Dr. Adolfo Pons Hospital and of the Ibero-American Journal of Applied Research. Member of the Venezuelan Society of Microbiology, Member of the American Society of Tropical Medicine and Hygiene (ASTMH) and Member of the Venezuelan Association for the Advancement of Science (AsoVAC).

E-mail: nere98@hotmail.com  valero.nereida@gmail.com

ORCID ID: https://orcid.org/0000-0003-3496-8848

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Published
2020-05-12
How to Cite
1.
Valero Cedeño NJ, Veliz-Castro TI, Edison Gastón PP, Merchán-Villafuerte KM, Gotera J. Lipids, Malnutrition and Dengue Infection: Association or repercussion?. Kasmera [Internet]. 2020May12 [cited 2024May18];48(1):e48131764. Available from: https://www.produccioncientificaluz.org/index.php/kasmera/article/view/31764
Issue
Vol. 48 No. 1 (2020)
Section
Essays

Copyright (c) 2020 Nereida Josefina Valero Cedeño, Teresa Isabel Veliz-Castro, Pincay Parrales Edison Gastón, Karina Maricela Merchán-Villafuerte, Jenifer Gotera

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