El Premio Nobel de Medicina o Fisiología 2023.
The 2023 Nobel Prize in Medicine or Physiology.
Abstract
The 2023 Nobel Prize in Medicine or Physiology, awarded to Katalin Karikó and Drew Weissman, recognizes the fundamental discovery that the modification of bases in mRNA synthesized in vitro prevents inflammatory responses and increases protein production when it is introduced into the cell. Although these discoveries received little attention when they were published between 2005 and 2010, ten years later they made possible the rapid development of vaccines against COVID-19.
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References
Norrby E. Yellow fever and Max Theiler: the only Nobel Prize for a virus Vaccine. J Exp Med 2007. 204(12):2779-2784.
The Nobel Assembly at the Karolinska Institutet. Press Release. The 2023 Nobel Prize in Medicine or Physiology. https://www.nobelprize.org/prizes/medicine/2023/advanced-information/
Karikó K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005. 23:165-175.
Karikó K, Muramatsu H, Welsh FA, Ludwig J, Kato H, Akira S, Weissman D. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol Ther 2008. 16:1833-1840.
Anderson BR, Muramatsu H, Nallagatla SR, Bevilacqua PC, Sanding LH, Weissman D, Karikó K. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acid Res 2010. 38:5884-5892.
Stuart LM. In gratitude for mRNA vaccines. New Eng J Med 2021. 385:1435-1438.
Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature 2020. 586:567-571.
Dolgin E. The tangled history of mRNA vaccines. Nature 2021. 597:318-324.
The Nobel Assembly at the Karolinska Institutet. Press Release. The 2023 Nobel Prize in Medicine or Physiology. https://www.nobelprize.org/prizes/medicine/2023/advanced-information/
Karikó K, Buckstein M, Ni H, Weissman D. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005. 23:165-175.
Karikó K, Muramatsu H, Welsh FA, Ludwig J, Kato H, Akira S, Weissman D. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol Ther 2008. 16:1833-1840.
Anderson BR, Muramatsu H, Nallagatla SR, Bevilacqua PC, Sanding LH, Weissman D, Karikó K. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acid Res 2010. 38:5884-5892.
Stuart LM. In gratitude for mRNA vaccines. New Eng J Med 2021. 385:1435-1438.
Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature 2020. 586:567-571.
Dolgin E. The tangled history of mRNA vaccines. Nature 2021. 597:318-324.
Published
2023-11-20
How to Cite
Esparza, J. (2023). El Premio Nobel de Medicina o Fisiología 2023.: The 2023 Nobel Prize in Medicine or Physiology. Investigación Clínica, 64(4), 437-439. https://doi.org/10.54817/IC.v64n4a00
Section
Editorial
