Efecto protector del tetraborato de sodio sobre los perfiles de ácidos grasos en el corazon de ratas, expuestas a toxicidad por plomo
Resumen
Este estudio fue diseñado para observar los efectos del tetraborato de sodio en la prevención del daño causado por la toxicidad del metal plomo a los ácidos grasos en el tejido cardíaco de ratas. Tras homogeneizar el tejido cardíaco con tampón Tris-HCl, el sedimento separado se preparó para el análisis de ácidos grasos. Los ácidos grasos del extracto lipídico obtenido se transformaron en éster metílico y se analizaron mediante cromatografía de gases SHIMADZU GC 2010 PLUS. Al comparar el grupo plomo con el grupo plomo + tetraborato de sodio, se observaron aumentos parciales en los niveles de ácidos grasos saturados como ácido mirístico (14:0), ácido pentadecanoico (15:0) y ácido palmítico (16:0), mientras que se observaron aumentos variables en algunos niveles de ácidos grasos monoinsaturados como ácido palmitoleico (16:1, n-7) y ácido oleico (18:1, n-9). Además, se observaron aumentos variables en todos los ácidos grasos poliinsaturados, excluyendo los ácidos grasos ácido araquidónico (20:4, n-6) y ácido adrenérgico (22:4, n-6). El cambio más notable en los ácidos grasos en nuestro estudio, el aumento del ácido graso ácido araquidónico (20:4, n-6) en el grupo tratado con plomo, mientras que disminuyó en el grupo tratado con tetraborato de sodio, demuestra que tetraborato de sodio disminuyó los efectos negativos del estrés oxidativo sobre los ácidos grasos. Los resultados de este estudio proporcionan evidencia que respalda el uso potencial de tetraborato de sodio en el diseño de fármacos para prevenir los efectos tóxicos del plomo.
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