Los efectos de la aplicación de Meloxicam sobre la calidad de vida y el desarrollo en terneros

• Halil Sennaroglu Near East University, Faculty of Veterinary Medicine. North Cyprus, Mersin–10, Turkey
• Selim Aslan Near East University, Faculty of Veterinary Medicine. North Cyprus, Mersin–10, Turkey
• Kamil Seyrek Intas Near East University, Faculty of Veterinary Medicine. North Cyprus, Mersin–10, Turkey

DOI: https://doi.org/10.52973/rcfcv-e33276

Palabras clave: Meloxicam, terneros, calidad de vida, animal, Holstein vaca

Resumen

Si bien se afirma que existe un aumento en las tasas de pérdida de terneros a nivel mundial y especialmente en las granjas lecheras modernas, este tema, que es un problema de bienestar animal internacional, no ha sido adecuadamente definido a nivel nacional, de granja grande o de granja pequeña. nivel en la mayoría de los países en desarrollo. La tasa de muertes de terneros antes, durante y después del parto es de 2 a 20 % en novillas y vacas. Estudios previos mostraron que el 75 % de las muertes ocurren durante el nacimiento o dentro de la primera hora después del nacimiento, el 10 % antes del nacimiento y el 15 % dentro de las 48 horas posteriores al nacimiento. Este estudio tuvo como objetivo determinar el efecto de la administración de meloxicam en la calidad de vida y desarrollo de los terneros. Se utilizó un método experimental para lograr el objetivo de esta investigación. Se incluyeron en el estudio para el grupo de estudio un total de 60 Holstein terneros, 30 en el grupo experimental y 30 en el grupo de control. Se administró MELOXICAM (0,5 mg·kg^-1)a la vaca madre y al ternero inmediatamente después del nacimiento, 2 días antes del parto esperado. En este estudio, se pasó un proceso de 8 semanas para recolectar los datos. Se concluyó que el meloxicam no afectó los valores de BHBA de las vacas maternas. Ningún ternero murió por neumonía y enfermedades relacionadas con la diarrea después de haber sido tratado con meloxicam. A partir de los valores de proteína total y albúmina total de los terneros, se concluyó que el meloxicam no afectó la relación de proteína, pero sí la relación de albúmina. Se concluyó que la aplicación de meloxicam incrementó la actividad vital de los terneros.

Citas

Degirmenci F, Yılmaz DV, Uzel A. Evidence Based Care for Couples with Fertility Problems. Intern. J. Emer. Trends Health Sci. [Internet]. 2019; 3(1):22–28. doi: https://doi.org/kkr9

Azzouz A, Jurado–Sánchez B, Souhail B, Ballesteros E. Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography–mass spectrometry. Agric. Food Chem. [Internet]. 2011; 59(9):5125–5132. doi: https://doi.org/dqqw2h

Coetzee JF, Mosher RA, Kohake LE, Cull CA, Kelly LL, Mueting SL, KuKanich B. Pharmacokinetics of oral gabapentin alone or co–administered with Meloxicam in ruminant beef calves. The Vet. J. [Internet]. 2011; 190(1):98–102. doi: https://doi.org/b8wd48

Satilmis M, Bilgili A. New Usage Options of Nonsteroidal Anti–inflammatory Drugs. J. Fac. Vet. Med. Erciyes Univ. [Internet]. 2013 [cited 20 May 2023]; 10:63–71. Available in: https://bit.ly/43DzFM5.

Ari UC, Pancarci SM, Kacar C, Gungor O, Lehimcioglu NC, Ozturkler Y, Yildiz S. Effect of progestagen application during Ovsynch protocol on pregnancy rates of lactating–grazing cows. Kafkas Univ. Vet. Fak. Derg. [Internet]. 2017; 23(2):319–324. doi: https://doi.org/kksb

Ong CKS, Lirk P, Tan CH, Seymour RA. An evidence–based update on nonsteroidal anti–inflammatory drugs. Clin. Med. Res. [Internet]. 2007; 5(1):19–34. doi: https://doi.org/b549jg

Alkan H, Erdem H. Reproductive use of nonsteroidal antiinflammatory drugs in cows. Ataturk Univ. J. Vet. Sci. [Internet]. 2018; 13(1):112–120. doi: https://doi.org/kksc

Friton GM, Schmidt H, Schrodl W. Clinical and anti‐inflammatory effects of treating endotoxin‐challenged pigs with Meloxicam. Vet. Rec. [Internet]. 2006; 159(17):552–557. doi: https://doi.org/b6k9fd

Bulut HY, Ulusoy–Severcan E, Goktug A, Ozdemir G, Ertugrul A. Two adolescent cases presenting with anaphylaxis affecting cardiovascular system. Revue Française d'Allergologie. [Internet]. 2023; 63(2):103280. doi: https://doi.org/kksd

Velpandian T, Jaiswal J, Bhardwaj RK, Gupta SK. Development and validation of a new high–performance liquid chromatographic estimation method of Meloxicam in biological samples. J. Chromatogr. B: Biomed. Sci. Appl. [Internet]. 2000; 738(2):431–436. doi: https://doi.org/fwx9px

Karademir U. Kopeklere Tepoksalin, Meloxicam ve Karprofenin agız yolu ile uygulanmasını takiben karsılastırmalı farmakokinetikleri. [doctoral thesis on the Internet]. Turkey: Adnan Menderes University; 2009 [cited 10 March 2023]. 78 p. Available in: https://bit.ly/3rF4vXg.

Erdem H, Guzeloglu A. Effect of Meloxicam treatment during early pregnancy in Holstein heifers. Reprod. Dom. Anim. [Internet]. 2010; 45:625–628. doi: https://doi.org/cr5pbh

Ozyurtlu N, Cetin Y, Kucukaslan I, Kocamuftuoglu M. Effect of Flunixin Meglumine, Meloxicam and PGE2 Administrations After Insemination on Pregnancy Rates in Cows. Harran. Univ. Vet. Fak. Derg. [Internet]. 2016 [cited 15 May 2023]; 5(2):105–109. Available in: https://bit.ly/3K90wbU.

Fraccaro E, Coetzee JF, Odore R, Edwards–Callaway LN, Kukanich B, Badino P, Bergamasco L. A study to compare circulating flunixin, Meloxicam, and gabapentin concentrations with prostaglandin E2 levels in calves undergoing dehorning. Res. Vet. Sci. [Internet]. 2013; 95(1):204–211. doi: https://doi.org/f42jk5

Patterson DJ, Bellows RA, Burfening PJ, Carr JB. Occurrence of neonatal and postnatal mortality in range beef cattle. I. Calf loss incidence from birth to weaning, backward and breech presentations, and effects of calf loss on subsequent pregnancy rate of dams. Theriogenol. [Internet]. 1987; 28:557–571. doi: https://doi.org/bncfj7

Alan M, Tasal İ, Cetin Y, Saban E, Uyar A. Prediction of Postpartum Ovarian Activity by Serum Progesteron Levels and Clinical Observations in Cows. YYU Vet. Fak. Derg. [Internet]. 2000 [cited 15 May 2023]; 11:60–64. Available in: https://bit.ly/3Y5dSeT.

Bayyit E, Merhan O. Some Acute Phase Proteins and Oxidative Stress Level in Cows with Normal Parturition and Dystocia. Vet. Sci. Prod. [Internet]. 2020; 15(2): 145–150. doi: https://doi.org/kksf

Koyuncu M, Karaca M. Buzagılarda Yasama Gucunun Anahtarı; “Kolostrum”. (Key of Survival in Calves “Colostrum”). J. Anim. Prod. [Internet]. 2018; 59(1):67–78. doi: https://doi.org/kksg

Godden S. Colostrum management for dairy calves. Vet. Clin. North Ame.: Food Anim. Pract. [Internet]. 2008; 24(1):19–39. doi: https://doi.org/czr4s3

Zhang Ly, Qu Pb, Tu Y, Yang Ct, Diao Y. Effects of flavonoids from mulberry leaves and candida tropicalis on performance and nutrient digestibility in calves. Kafkas Univ. Vet. Fak. Derg. [Internet]. 2017; 23(3):473–479. doi: https://doi.org/gm6946

Duncan NB, Stoecklein KS, Foote AP, Meyer AM. Dam parity affects fetal growth, placental size, and neonatal metabolism in spring–born beef calves. J. Anim. Sci. [Internet]. 2023; 101:e–skac399. doi: https://doi.org/kksq

Keles I, Ekinci G, Tufekci E, Citil M, Gunes, V, Aslan, O, Deniz O. Etiological and predisposing factors in calves with neonatal diarrhea: A clinical study in 270 case series. Kafkas Univ. Vet. Fak. Derg. [Internet]. 2022; 28:315–326. doi: https://doi.org/kdr4

Kozat S. The Importance of Colostrum Management in Newborn Calves. Ataturk Univ. J. Vet. Sci. [Internet]. 2019; 14(3):343–353. doi: https://doi.org/kksr

Maden M, İder M, Erturk A. Sudden Death, Causes and Diagnostic Approaches in Dairy Cattle: Traditional Review. Turkiye Klinikleri J. Vet. Sci. [Internet]. 2021; 12:22–36. doi: https://doi.org/kkss

Yanar KE. Causes, Treatments and Methods for Prevention of Neonatal Calf Diarrhea. Palandoken J. Anim. Sci. Tech. Econom. [Internet]. 2022 [cited 12 May 2023]; 1:54–59. Available in: https://bit.ly/3QexMCB.

Sahal M, Terzi OS, Ceylan E, Kara E. Calf diarrhea and prevention methods. J. Lalahan Livest. Res. Instit. [Internet]. 2018 [cited 15 May 2023]; 58:41–49. Available in: https://bit.ly/3O65PtH.

Latosinski GS, Amzalak MJ, Pantoja JCF. Efficacy of ketoprofen for treatment of spontaneous, culture–negative, mild cases of clinical mastitis: A randomized, controlled superiority trial. J. Dairy Sci. [Internet]. 2020; 103(3):2624–2635. doi: https://doi.org/gm6946

Dursun S, Kose M, Kizil SH, Bulut G, Ozturk C, Atli MO, Karasahin T. Foliküler Kistli Holstein Irkı Duvelerde Ovsynch Protokolunun Gebelik Oranları Uzerine Etkisi. (The Effect of Ovsynch Protocol on Pregnancy Rates in Holstein Heifers with Follicular Cysts). Erciyes Univ. Vet. Fak. Der. [Internet]. 2023; 20(1):8–13. doi: https://doi.org/kkst

Daeseleire E, Mortier L, De Ruyck H, Geerts N. Determination of flunixin and ketoprofen in milk by liquid chromatography–tandem mass spectrometry. Analyt. Chim. Acta. [Internet]. 2003; 488(1):25–34. doi: https://doi.org/d7rfkx

Dursun S, Laktasyonda olmayan Isvicre esmeri inek ve duvelerde ketoprofen ve flunixin meglumin uygulamasinin gebe kalma orani uzerine etkisi (The effect of ketoprofen and flunixin meglumine treatment and pregnancy rate in brown swiss non–lactating cows and heifers) [doctoral thesis on the Internet]. Turkey: Selcuk University; 2011 [cited 13 March 2023]. 129 p. Available in: https://bit.ly/46UD2kF.

Simões, J, Stilwell, G. Calving Management and Newborn Calf Care: An interactive Textbook for Cattle Medicine and Obstetrics. Springer; 2021. Chapter, Normal Birth (Eutocia); p. 51–79.

Apgar V, Holaday DA, James LS, Weisbrot IM, Berrien C. Evaluation of the newborn infant–second report. J. Ame. Med. Assoc. [Internet]. 1958; 168(15):1985–1988. doi: https://doi.org/dwkncj

Murray CF, Leslie KE. Newborn calf vitality: Risk factors, characteristics, assessment, resulting outcomes and strategies for improvement. The Vet. J. [Internet]. 2013; 198(2):322–328. doi: https://doi.org/f5mkxq

Ayrapetyan M, Talekar K, Schwabenbauer K, Carola D, Solarin K, McElwee D, Aghai ZH. Apgar scores at 10 minutes and outcomes in term and late preterm neonates with hypoxic–ischemic encephalopathy in the cooling era. Ame. J. Peru. [Internet]. 2019; 36(5):545–554. doi: https://doi.org/grq8fn

Windeyer MC, Leslie KE, Godden SM, Hodgins DC, Lissemore KD, LeBlanc SJ. Factors associated with morbidity, mortality, and growth of dairy heifer calves up to 3 months of age. Prev. Vet. Med. [Internet]. 2014; 113(2):231–240. doi: https://doi.org/f5phdr

Bae YJ, Kang SJ, Park KS. Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin–protein ligase. Insect Biochem. Mol. Biol. [Internet]. 2007; 37(5):430–439. doi: https://doi.org/d62z87

Noble G, Edwards S, Lievaart J, Pippia J, Boston R, Raida S. Pharmacokinetics and Safety of Single and Multiple Oral Doses of Meloxicam in Adult Horses. J. Vet. Intern. Med. 2012; 26:1192–1201.

Akyuz B, Sariozkan S, Bayram D. The Prevalence of BLAD and Comparison of Some Production Parameters in Carrier and Non–Carrier Holstein Cows in Kayseri Province, Turkey. J. Fac. Vet. Med. Erciyes Univ. [Internet]. 2005 [cited 10 March 2023]; 12(1):31–35. Available in: https://bit.ly/44Dmn3h.

Muz MN, Ozturk, AS, Karakavuk M. Acute Babesiosis in A Nine–Day Old Male Calf. AVKAE. [Internet]. 2013 [cited 18 May 2023]; 3(1):55–57. Available in: https://bit.ly/43EVISH.

Akyuz E, Naseri A, Erkilic EE, Makav M, Uzlu E, Kirmizigul AH, Gokce G. Neonatal buzagı ishalleri ve sepsis. Kafkas Univ. Fen. Bil. E. Der. [Internet]. 2017 [cited 14 April 2023]; 10(2):181–191. Available in: https://bit.ly/44XhT7v.

Kozat S, Tuncay I. Prevalence of Rotavirus, Coronavirus, Cryptosporidium spp., Escherichia coli K 99, and Giardia lamblia pathogens in neonatal calves with diarrheic in Siirt Region. Van Vet. J. [Internet]. 2018 [cited 14 April 2023]; 29(1):17–22. Available in: https://bit.ly/3OprxKB.

Abdeldjalil D. Acquired obstructive urolithiasis in male Camelus dromedarius from southeast Algeria: Report of 11 cases. J. Camel. Sci. [Internet]. 2020 [cited 12 May 2023]; 13:56–65. Available in: https://bit.ly/3DpYQXJ.

Kumar M, Kumar A. Effect of herbal treatment on haemato–biochemical recovery in a Colibacillosis calves. Pharma Innovation [Internet]. 2021 [cited 12 May 2023]; SP–10(8):303–307. Available in: https://bit.ly/3QeH7u9.

Karaca M. Hendek ilcesi sut sigirciligi isletmelerinde buzagilarda yasama gucu ile ilgili yonetsel uygulamalar (Managerial practices related to the power survival of calves in dairy cattle breeding enterpires in Hendek district) [doctoral thesis on the Internet]. Turkey: Bursa Uludag University; 2020 [cited 13 April 2023]. 210 p. Available in: https://bit.ly/3KbrTSz.