Evaluation of thyroid function and metabolic parameters in obese and overweight children: A prospective case-control study.
Evaluación de la función tiroidea y los parámetros metabólicos en niños obesos y con sobrepeso: Un estudio prospectivo de casos y controles.
Palabras clave:
índice de masa corporal, insulina, parámetros metabólicos, obesidad, hormona tiroidea
Resumen
La obesidad se considera un importante desafío de salud pública mundial y su prevalencia está aumentando rápidamente en los niños. En este estudio, se investigó si el nivel normal superior de TSH puede estar asociado con los parámetros del síndrome metabólico, incluida la obesidad, la presión arterial elevada, cambios en los lípidos y la sensibilidad a la insulina, en niños con sobrepeso y obesidad. También investigamos si existe una relación entre el IMC y estos parámetros. En este estudio prospectivo de casos y controles se incluyeron a 145 participantes (74 hembras, 71 varones) de entre 5 y 18 años. Los participantes se dividieron en 3 grupos según el puntaje z del IMC, como sobrepeso, obesidad y control. El grupo de control incluyó 35 sujetos sanos emparejados por edad y sexo. Los niveles de hormona estimulante de la tiroides de los grupos de control, con sobrepeso y obesos fueron 2,14 ± 1,27, 2,97 ± 1,26 y 3,13 ± 1,11, respectivamente (p <0,05). Hubo una correlación positiva significativa entre la TSH y el BMI, la puntuación z del IMC entre los grupos con sobrepeso y obesidad (r = 0,302, p = 0,000), (r = 0,121, p = 0,004), respectivamente. Por esa razón, el nivel de TSH en el rango normal alto debe considerarse como un factor de riesgo del síndrome metabólico y sus componentes.
Descargas
La descarga de datos todavía no está disponible.
Citas
Nittari G, Scuri S, Petrelli F, Pirillo I, di Luca NM, Grappasonni I. Fighting obesity in children from European World Health Organization member states. Epidemiological data, medical-social aspects, and prevention programs. Clin Ter 2019;170:223-230.
Topal F, Goren H, Yucel F, Sahinturk V, Aydar Y. Effect of consuming high-fat diet on the morphological parameters of adrenal gland. Bratisl Med J 2019;120: 593 – 600.
Zhang A, Li S, Zhang Y, Jiang F, Jin X, Ma J. Nocturnal enuresis in obese children: a nation-wide epidemiological study from China. Sci Rep 2019;9:8414.
Khatiwada S, Sah SK, Kc R, Baral N, Lamsal M. Thyroid dysfunction in metabolic syndrome patients and its relationship with components of metabolic syndrome. Clin Diabetes Endocrinol 2016;2:3-7.
Gajda SN, Kuryłowicz A, Żach M, Bednarczuk T, Wyleżoł M. Diagnosis and treatment of thyroid disorders in obese patients - what do we know? Endokrynol Pol 2019;70:271-276.
Serum thyroid-stimulating hormone levels and body mass index percentiles in children with primary hypothyroidism on levothyro- xine replacement. J Clin Res Pediatr Endocrinol 2017;9:337-343.
Sheehan MT. Biochemical testing of the thyroid: TSH is the best and, oftentimes, only test needed. A review for primary care. Clin Med Res 2016;14:83-92.
Le TN, Celi FS, Wickham EP. Thyrotropin levels are associated with cardiometabolic risk factors in euthyroid adolescents. Thyroid 2016;26:1441-1449.
Chen Y, Chen Y, Wang N, Chen C, Nie X, Li Q, Han B, Lu Y. Thyroid stimulating hormone within the reference range is associated with visceral adiposity index and lipid accumulation product: A population-based study of SPECT-China. Horm Metab Res 2018;50:29-36.
Rahbar AR, Kalantarhormozi M, Izadi F, Arkia E, Rashidi M, Pourbehi F, Daneshifard F, Rahbar A. Relationship between body mass index, waist-to-hip ratio, and serum lipid concentrations and thyroid-stimulating hormone in the euthyroid adult population. Iran J Med Sci 2017;42:301-305.
Broeders EP, Vijgen GH, Havekes B, Bouvy ND, Mottaghy FM, Kars M, Schaper NC, Schrauwen P, Brans B, van Marken Lichtenbelt WD. Thyroid hormone activates brown adipose tissue and increases non-shivering thermogenesis. A cohort study in a group of thyroid carcinoma patients. PLoS One 2016;11:e0145049.
Sayarifard F, Yaghmaie B, Sayarifard A, Mohammadpour M, Sharifzadeh M, Abbasi F, Haghi-Ashtiani MT, Kouhnavard M. Thyroid function tests in critically ill children; any correlation with disease severity or outcome? Iran J Pediatr 2018; 28:e69397.
Asvold BO, Bjøro T, Vatten LJ. Association of serum TSH with high body mass differs between smokers and never-smokers. J Clin Endocrinol Metab 2009;94:5023-5027.
Asvold BO, Vatten LJ, Nilsen TIL, Bjøro T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT study. Eur J Endocrinol 2007;156:181-186.
Rumińska M, Witkowska-Sędek E, Majcher A, Pyrżak B. Thyroid function in obese children and adolescents and Its association with anthropometric and metabolic parameters. Adv Exp Med Biol 2016;912:33-41.
Çelmeli G, Çürek Y, Arslan Gülten Z, Yardımsever M, Koyun M, Akçurin S, Bircan İ. Remarkable increase in the prevalence of overweight and obesity among school age children in Antalya, Turkey, Between 2003 and 2015. J Clin Res Pediatr Endocrinol 2019;11:76-81.
Aras Ş, Üstünsoy S, Armutçu F. Indices of central and peripheral obesity; Anthropometric measurements and laboratory parameters of metabolic syndrome and thyroid function. Balkan Med J 2015;32:414-420.
Agbaht K, Mercan Y, Kutlu S, Alpdemir MF, Sezgin T. Obesity with and without metabolic syndrome: Do vitamin D and thyroid autoimmunity have a role? Diabetes Res Clin Pract 2014;106:27-34.
Witkowska-Sędek E, Kucharska A, Rumińska M, Pyrżak B. Thyroid dysfunction in obese and overweight children. Endokrynol Pol 2017;68:54.
Javed A, Balagopal PB, Vella A, Fischer PR, Piccinini F, Dalla Man C, Cobelli C, Giesler PD, Laugen JM, Kumar S. Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents. Thyroid 2015;25:478-484.
Xu B, Yang H, Wang Z, Yang T, Guo H, Cheng P, He W, Sun M, Chen H, Duan Y. Elevated thyroid stimulating hormone levels are associated withmetabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older. J Biomed Res 2016;30:476-482.
Marras V, Casini MR, Pilia S, Carta D, Civolani P, Porcu M, Uccheddu AP, Loche S. Thyroid function in obese children and adolescents. Horm Res Paediatr 2010;73:193- 197.
Aeberli I, Jung A, Murer SB, Wildhaber J, Wildhaber-Brooks J, Knöpfli BH, Zimmermann MB. During rapid weight loss in obese children, reductions in TSH predict improvements in insulin sensitivity independent of changes in body weight or fat. J Clin Endocrinol Metab 2010;95:5412-5418.
Ghergherehchi R, Hazhir N. Thyroid hormonal status among children with obesity. Ther Adv Endocrinol Metab 2015;6:51-55.
Reinehr T, Isa A, De Sousa G, Dieffenbach R, Andler W. Thyroid hormones and their relation to weight status. Horm Res 2008;70:51-57.
Liu HY, Deng AM, Zhou Y, Yao DK, Xu DX, Zhong RQ. Analysis of HLA alleles polymorphism in Chinese patients with primary biliary cirrhosis. Hepatobiliary Pancreat Dis Int 2006;5:129-132.
Harel Z, Riggs S, Vaz R, Flanagan P, Harel D. Isolated low HDL cholesterol emerges as the most common lipid abnormality among obese adolescents. Clin Pediatr (Phila) 2010;49:29-34.
Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000;160:526-534.
Nader NS, Bahn RS, Johnson MD, Weaver AL, Singh R, Kumar S. Relationships between thyroid function and lipid status or insulin resistance in a pediatric Population. Thyroid 2010;20:1333-1339.
Aksoy N, Yeler MT, Ayan NN, Ozkeskin A, Ozkan Z, Serin NO. Association between thyroid hormone levels and insulin resistance and body mass index. Pakistan J Med Sci 2015;31:1417-1420.
Palma CC, Pavesi M, Nogueira VG, Clemente EL, Vasconcellos Mde F, Pereira LC Júnior, Pacheco FF, Braga TG, Bello Lde F, Soares JO, Dos Santos SC, Campos VP, Gomes MB. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Diabetol Metab Syndr 2013;5:58.
Ambrosi B, Masserini B, Iorio L, Delnevo A, Malavazos AE, Morricone L, Sburlati LF, Orsi E. Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects. J Endocrinol Invest 2010;33:640-643.
De Jesús Garduño-Garcia J, Camarillo Romero E, Loe Ochoa A, Romero-Figueroa S, Huitron Bravo G, Torres García R, Montenegro-Morales P, Mendieta-Zerón H. Thyroid function is associated with insulin resistance markers in healthy adolescents
with risk factors to develop diabetes. Diabetol Metab Syndr 2015;7:1-6.
Liu J, Duan Y, Fu J, Wang G. Association between thyroid hormones, thyroid antibodies, and cardiometabolic factors in non-obese individuals with normal thyroid function. Front Endocrinol (Lausanne) 2018;9:1-6.
Nozarian Z, Abdollahi A, Mehrtash V, Nasiri Bonaki H. Upper normal limit of thyroid- stimulating hormone and metabolic syndrome in Iranian patients with obesity. Iran J Pathol 2017;12:88-93.
Witte T, Ittermann T, Thamm M, Riblet NB, Völzke H. Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth. J Clin Endocrinol Metab 2015;100:2090-2097.
Ren R, Ma Y, Deng F, Li T, Wang H, Wei J, Jiang X, He M, Tian M, Liu D, Chen B, Deng W. Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study. Diabetes Metab Syndr Obes 2019;12:1563-1569.
Åsvold BO, Vatten LJ, Midthjell K, Bjøro T. Serum TSH within the reference range as a predictor of future hypothyroidism and hyperthyroidism: 11-year follow-up of the HUNT Study in Norway. J Clin Endocrinol Metab 2012;97:93–99.
Topal F, Goren H, Yucel F, Sahinturk V, Aydar Y. Effect of consuming high-fat diet on the morphological parameters of adrenal gland. Bratisl Med J 2019;120: 593 – 600.
Zhang A, Li S, Zhang Y, Jiang F, Jin X, Ma J. Nocturnal enuresis in obese children: a nation-wide epidemiological study from China. Sci Rep 2019;9:8414.
Khatiwada S, Sah SK, Kc R, Baral N, Lamsal M. Thyroid dysfunction in metabolic syndrome patients and its relationship with components of metabolic syndrome. Clin Diabetes Endocrinol 2016;2:3-7.
Gajda SN, Kuryłowicz A, Żach M, Bednarczuk T, Wyleżoł M. Diagnosis and treatment of thyroid disorders in obese patients - what do we know? Endokrynol Pol 2019;70:271-276.
Serum thyroid-stimulating hormone levels and body mass index percentiles in children with primary hypothyroidism on levothyro- xine replacement. J Clin Res Pediatr Endocrinol 2017;9:337-343.
Sheehan MT. Biochemical testing of the thyroid: TSH is the best and, oftentimes, only test needed. A review for primary care. Clin Med Res 2016;14:83-92.
Le TN, Celi FS, Wickham EP. Thyrotropin levels are associated with cardiometabolic risk factors in euthyroid adolescents. Thyroid 2016;26:1441-1449.
Chen Y, Chen Y, Wang N, Chen C, Nie X, Li Q, Han B, Lu Y. Thyroid stimulating hormone within the reference range is associated with visceral adiposity index and lipid accumulation product: A population-based study of SPECT-China. Horm Metab Res 2018;50:29-36.
Rahbar AR, Kalantarhormozi M, Izadi F, Arkia E, Rashidi M, Pourbehi F, Daneshifard F, Rahbar A. Relationship between body mass index, waist-to-hip ratio, and serum lipid concentrations and thyroid-stimulating hormone in the euthyroid adult population. Iran J Med Sci 2017;42:301-305.
Broeders EP, Vijgen GH, Havekes B, Bouvy ND, Mottaghy FM, Kars M, Schaper NC, Schrauwen P, Brans B, van Marken Lichtenbelt WD. Thyroid hormone activates brown adipose tissue and increases non-shivering thermogenesis. A cohort study in a group of thyroid carcinoma patients. PLoS One 2016;11:e0145049.
Sayarifard F, Yaghmaie B, Sayarifard A, Mohammadpour M, Sharifzadeh M, Abbasi F, Haghi-Ashtiani MT, Kouhnavard M. Thyroid function tests in critically ill children; any correlation with disease severity or outcome? Iran J Pediatr 2018; 28:e69397.
Asvold BO, Bjøro T, Vatten LJ. Association of serum TSH with high body mass differs between smokers and never-smokers. J Clin Endocrinol Metab 2009;94:5023-5027.
Asvold BO, Vatten LJ, Nilsen TIL, Bjøro T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT study. Eur J Endocrinol 2007;156:181-186.
Rumińska M, Witkowska-Sędek E, Majcher A, Pyrżak B. Thyroid function in obese children and adolescents and Its association with anthropometric and metabolic parameters. Adv Exp Med Biol 2016;912:33-41.
Çelmeli G, Çürek Y, Arslan Gülten Z, Yardımsever M, Koyun M, Akçurin S, Bircan İ. Remarkable increase in the prevalence of overweight and obesity among school age children in Antalya, Turkey, Between 2003 and 2015. J Clin Res Pediatr Endocrinol 2019;11:76-81.
Aras Ş, Üstünsoy S, Armutçu F. Indices of central and peripheral obesity; Anthropometric measurements and laboratory parameters of metabolic syndrome and thyroid function. Balkan Med J 2015;32:414-420.
Agbaht K, Mercan Y, Kutlu S, Alpdemir MF, Sezgin T. Obesity with and without metabolic syndrome: Do vitamin D and thyroid autoimmunity have a role? Diabetes Res Clin Pract 2014;106:27-34.
Witkowska-Sędek E, Kucharska A, Rumińska M, Pyrżak B. Thyroid dysfunction in obese and overweight children. Endokrynol Pol 2017;68:54.
Javed A, Balagopal PB, Vella A, Fischer PR, Piccinini F, Dalla Man C, Cobelli C, Giesler PD, Laugen JM, Kumar S. Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents. Thyroid 2015;25:478-484.
Xu B, Yang H, Wang Z, Yang T, Guo H, Cheng P, He W, Sun M, Chen H, Duan Y. Elevated thyroid stimulating hormone levels are associated withmetabolic syndrome in a Chinese community-based population of euthyroid people aged 40 years and older. J Biomed Res 2016;30:476-482.
Marras V, Casini MR, Pilia S, Carta D, Civolani P, Porcu M, Uccheddu AP, Loche S. Thyroid function in obese children and adolescents. Horm Res Paediatr 2010;73:193- 197.
Aeberli I, Jung A, Murer SB, Wildhaber J, Wildhaber-Brooks J, Knöpfli BH, Zimmermann MB. During rapid weight loss in obese children, reductions in TSH predict improvements in insulin sensitivity independent of changes in body weight or fat. J Clin Endocrinol Metab 2010;95:5412-5418.
Ghergherehchi R, Hazhir N. Thyroid hormonal status among children with obesity. Ther Adv Endocrinol Metab 2015;6:51-55.
Reinehr T, Isa A, De Sousa G, Dieffenbach R, Andler W. Thyroid hormones and their relation to weight status. Horm Res 2008;70:51-57.
Liu HY, Deng AM, Zhou Y, Yao DK, Xu DX, Zhong RQ. Analysis of HLA alleles polymorphism in Chinese patients with primary biliary cirrhosis. Hepatobiliary Pancreat Dis Int 2006;5:129-132.
Harel Z, Riggs S, Vaz R, Flanagan P, Harel D. Isolated low HDL cholesterol emerges as the most common lipid abnormality among obese adolescents. Clin Pediatr (Phila) 2010;49:29-34.
Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000;160:526-534.
Nader NS, Bahn RS, Johnson MD, Weaver AL, Singh R, Kumar S. Relationships between thyroid function and lipid status or insulin resistance in a pediatric Population. Thyroid 2010;20:1333-1339.
Aksoy N, Yeler MT, Ayan NN, Ozkeskin A, Ozkan Z, Serin NO. Association between thyroid hormone levels and insulin resistance and body mass index. Pakistan J Med Sci 2015;31:1417-1420.
Palma CC, Pavesi M, Nogueira VG, Clemente EL, Vasconcellos Mde F, Pereira LC Júnior, Pacheco FF, Braga TG, Bello Lde F, Soares JO, Dos Santos SC, Campos VP, Gomes MB. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Diabetol Metab Syndr 2013;5:58.
Ambrosi B, Masserini B, Iorio L, Delnevo A, Malavazos AE, Morricone L, Sburlati LF, Orsi E. Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects. J Endocrinol Invest 2010;33:640-643.
De Jesús Garduño-Garcia J, Camarillo Romero E, Loe Ochoa A, Romero-Figueroa S, Huitron Bravo G, Torres García R, Montenegro-Morales P, Mendieta-Zerón H. Thyroid function is associated with insulin resistance markers in healthy adolescents
with risk factors to develop diabetes. Diabetol Metab Syndr 2015;7:1-6.
Liu J, Duan Y, Fu J, Wang G. Association between thyroid hormones, thyroid antibodies, and cardiometabolic factors in non-obese individuals with normal thyroid function. Front Endocrinol (Lausanne) 2018;9:1-6.
Nozarian Z, Abdollahi A, Mehrtash V, Nasiri Bonaki H. Upper normal limit of thyroid- stimulating hormone and metabolic syndrome in Iranian patients with obesity. Iran J Pathol 2017;12:88-93.
Witte T, Ittermann T, Thamm M, Riblet NB, Völzke H. Association between serum thyroid-stimulating hormone levels and serum lipids in children and adolescents: a population-based study of german youth. J Clin Endocrinol Metab 2015;100:2090-2097.
Ren R, Ma Y, Deng F, Li T, Wang H, Wei J, Jiang X, He M, Tian M, Liu D, Chen B, Deng W. Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study. Diabetes Metab Syndr Obes 2019;12:1563-1569.
Åsvold BO, Vatten LJ, Midthjell K, Bjøro T. Serum TSH within the reference range as a predictor of future hypothyroidism and hyperthyroidism: 11-year follow-up of the HUNT Study in Norway. J Clin Endocrinol Metab 2012;97:93–99.
Publicado
2022-05-30
Cómo citar
Tuğba Kartal, A., Bozaykut, A., Gönül Sezer, R., & Güran, T. (2022). Evaluation of thyroid function and metabolic parameters in obese and overweight children: A prospective case-control study.: Evaluación de la función tiroidea y los parámetros metabólicos en niños obesos y con sobrepeso: Un estudio prospectivo de casos y controles. Investigación Clínica, 63(2), 126-136. https://doi.org/10.54817/IC.v63n2a02
Sección
Trabajos Originales
