Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals.

  • Bercy Uzcátegui Natural Products Laboratory, Faculty of Sciences, University of Zulia
  • Dinorah ívila Natural Products Laboratory, Faculty of Sciences, University of Zulia
  • Heberto Suárez-Roca Pharmacology Section, Instituto de Investigaciones Clínicas, Faculty of Medicine. University of Zulia, Maracaibo
  • Luis Quintero Pharmacology Section, Instituto de Investigaciones Clínicas, Faculty of Medicine. University of Zulia, Maracaibo
  • José Ortega Natural Products Laboratory, Faculty of Sciences, University of Zulia
  • Beatriz González Natural Products Laboratory, Faculty of Sciences, University of Zulia

Resumen

Lantana trifolia L. (Verbenaceae) is traditionally used as an anti-inflammatory medicinal plant in Venezuela. The methanol extract of the aerial parts of L. trifolia were assessed for the anti-inflammatory, anti-nociceptive and anti-pyretic properties. The extract produced an inhibition of carrageenan-induced edema in the rat paw over a dose range of 10-300 mg/kg i.p.; the dose-response curve was bell-shaped with a maximal effect at 100 mg/kg. The extract also produced a small but significant increase in the response latency of rats subjected to the hot plate, a thermal pain test that only detects analgesia by high-efficacy agents. The extract did not exhibit antipyretic activity. Thus, the L. trifolia extract could have therapeutically relevant anti-inflammatory and analgesic properties in humans.

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Publicado
2009-11-02
Cómo citar
Uzcátegui, B., ívilaD., Suárez-Roca, H., Quintero, L., Ortega, J., & González, B. (2009). Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals. Investigación Clínica, 45(4). Recuperado a partir de https://www.produccioncientificaluz.org/index.php/investigacion/article/view/28557
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