Efectos del ketorolaco sobre la anastomosis colorrectal en ratas

• Salim İlksen Başçeken Ankara University Faculty of Medicine, Department of General Surgery, Ankara, Türkiye https://orcid.org/0000-0002-0918-3208
• Nazmi Onur Okudur Ankara University Faculty of Medicine, Department of General Surgery, Ankara, Türkiye https://orcid.org/0000-0003-4175-8312
• Utku Tantoğlu Ankara University Faculty of Medicine, Department of General Surgery, Ankara, Türkiye https://orcid.org/0000-0002-7299-3318
• Şeref Dokcu Ankara University Faculty of Medicine, Department of General Surgery, Ankara, Türkiye https://orcid.org/0000-0001-9497-2190
• Deniz Tikici Health Sciences University, Gazi Yaşargil Training and Research Hospital, Department of General Surgery, Diyarbakır, Türkiye. https://orcid.org/0000-0003-1759-2973
• Nurian Ohri Ankara University Faculty of Medicine, Department of General Surgery, Ankara, Türkiye https://orcid.org/0000-0003-2957-6655
• Caner Baysan Izmir Democracy University, Department of Public Health, İzmir, Türkiye https://orcid.org/0000-0002-7675-1391
• Özge Tuğçe Paşaoğlu Gazi University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Türkiye https://orcid.org/0000-0002-5221-9034
• Hatice Paşaoğlu Gazi University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Türkiye https://orcid.org/0000-0001-8343-7432
• İbrahim Ethem Geçim Ankara University Faculty of Medicine, Department of General Surgery, Ankara, Türkiye https://orcid.org/0000-0002-6630-1442

DOI: https://doi.org/10.52973/rcfcv-e363918

Palabras clave: Fuga anastomótica, presión de ruptura anastomótica, anastomosis colorectal, ketorolaco, antiinflamatorios no esteroideos

Resumen

Las anastomosis colorrectales son procedimientos rutinarios en la cirugía gastrointestinal, aunque representan una causa importante de morbilidad y mortalidad. Diversos factores del paciente, la enfermedad y la técnica quirúrgica influyen en su cicatrización. El objetivo del estudio fue evaluar los efectos del Ketorolaco, empleado para la analgesia posoperatoria, sobre la continuidad de las anastomosis colorrectales y las adherencias intra-abdominales en un modelo experimental con ratas. Para ello se utilizaron treinta ratas Wistar Albinas, las cuales fueron asignadas aleatoriamente en tres grupos de diez ratas cada uno. Tras una anastomosis colorrectal término- terminal, los grupos recibieron 10 mg/kg de solución salina isotónica, 20 mg/kg de Meperidina o 1 mg/kg de Ketorolaco por vía intramuscular. En el séptimo día se resecó la línea anastomótica y se compararon el puntaje de Nair, la presión de ruptura y los niveles de hidroxiprolina. Los resultados obtenidos nos indicaron que no hubo diferencias significativas en los valores de hidroxiprolina (P = 0,566) ni en los puntajes de Nair (P = 0,118). Mientras que, las presiones de ruptura si difirieron significativamente (P = 0,017), siendo mayores en el grupo con Ketorolaco en compracion al grupo con Meperidina (P = 0,020). El uso perioperatorio de Ketorolaco no se asoció con fugas anastomóticas en este modelo experimental.

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